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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c72a6aa20025f5f12f35f35ef589c7a5c868a2b4ded551f2abc9dee048000a49' 
  AND token = 'dCIR0Usq4wH2wscsnuh8rGKfBQsmbBMSxjZr5wd7F+I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}