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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8afb81bdeba1b7dc218367667aebf7ea62b62262e0053b6040151abe34af8970' 
  AND token = 'hZ+aSbuC6XkhtAjotJz3J0+khO7rKBb72IG3Ah7mbAE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}