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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd53578b7d22de03282c6345ed9dfeaeaae030530b51960a1b626f12c8d70d045' 
  AND token = 'ZGCYXnfLPSKP8Tz7Q3AlOjSkSPUIBMbv2YQRkbBKN0A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}