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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '374cfd321bca07ab6b7389e5d6fbf00ccc18419cd91fb8d436f8969c8246b307' 
  AND token = 'Rf2GqFlckVXUDpQJGbXaleO1suNg0FBjx4Bvr0lVSEo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}