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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b757e48625ea9fe315544c8a0c2ad2b5cd6a25e70740818e265799ab03d474c2' 
  AND token = 'UwjAbIJq2/NUQs+VJyFwKwSrnx50Zc9HxedBVnsjQjs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}