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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4757ec301111da1156d478e9615a2b9295dde5534f55bc5266501f55d018f479' 
  AND token = '4f2nuT16/jAFUyNlJp+9UUZtS7x4IH7rjF/4ZXizXmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}